The ACSM5 Antibody (PAC015271) is a polyclonal antibody designed for research involving ACSM5, an enzyme involved in fatty acid metabolism. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the ACSM5 protein, researchers can detect and analyze this enzyme in various cell types, making it a valuable tool for studies in metabolism and lipid signaling pathways.ACSM5 plays a crucial role in fatty acid oxidation and energy production within cells. Dysregulation of ACSM5 has been linked to metabolic disorders and diseases such as obesity and diabetes, making it an important target for research in these areas.
Understanding the function and regulation of ACSM5 can provide valuable insights into metabolic processes and potential therapeutic targets for metabolic diseases.Overall, the ACSM5 Antibody is a reliable tool for studying the role of ACSM5 in cellular metabolism and metabolic disorders. Its high reactivity and specificity make it ideal for use in research aimed at uncovering the molecular mechanisms underlying metabolic diseases and developing novel treatments.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15271(ACSM5 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: PACO15271(ACSM5 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15271(ACSM5 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The acyl-CoA synthetase medium-chain (ACSM) family is comprised of ACSM1, ACSM2A, ACSM2B, ACSM3, ACSM4 and ACSM5, which encode for enzymes catalyzing the activation of medium-chain length fatty acid, ACSM5 is a 579 amino acid, protein has a broad substrate specificity and utilizes magnesium or manganese as a cofactor. ACSM5 is expressed in kidney and liver.
Synonyms:
acyl-CoA synthetase medium-chain family member 5
UniProt Protein Function:
ACSM5: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Carbohydrate Metabolism - butanoate; Mitochondrial; EC 6.2.1.2; LigaseChromosomal Location of Human Ortholog: 16p12.3
