The ACOT1 Polyclonal Antibody (PACO05017) is a vital tool for research involving ACOT1, an enzyme involved in fatty acid metabolism. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the ACOT1 protein, researchers can effectively detect and analyze its expression in different cell types, making it an essential component for studies in metabolism and lipid biology.ACOT1, also known as acyl-CoA thioesterase 1, plays a crucial role in lipid metabolism by catalyzing the hydrolysis of acyl-CoA esters. Its function in fatty acid metabolism makes it a key player in energy production and storage within cells.
Research into ACOT1 can provide insights into metabolic diseases such as obesity, diabetes, and cardiovascular disorders, as well as potential therapeutic strategies targeting lipid metabolism pathways.By utilizing the ACOT1 Polyclonal Antibody in their research, scientists can deepen their understanding of ACOT1's role in lipid metabolism and its implications in various metabolic disorders. This antibody serves as a valuable tool for investigating the molecular mechanisms underlying lipid homeostasis and metabolic regulation, offering new avenues for therapeutic interventions targeting fatty acid metabolism pathways.
Synthesized peptide derived from the Internal region of human ACOT1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ACOT1; CTE1; Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterase 1; CTE-I; CTE-Ib; Inducible cytosolic acyl-coenzyme A thioester hydrolase; Long chain acyl-CoA thioester hydrolase; Long chain acyl-CoA hydrolase
UniProt Protein Function:
ACOT1: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16. Belongs to the C/M/P thioester hydrolase family.Protein type: EC 3.1.2.2; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesisChromosomal Location of Human Ortholog: 14q24.3Cellular Component: cytosolMolecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activityBiological Process: acyl-CoA metabolic process; very-long-chain fatty acid metabolic process; long-chain fatty acid metabolic process
