The ABHD12 Rabbit Polyclonal Antibody (CAB17678) is a valuable tool for researchers studying ABHD12, an enzyme involved in lipid metabolism and cellular signaling pathways. This antibody, specifically raised in rabbits, is highly sensitive and specific for detecting ABHD12 protein in human samples, making it an ideal choice for Western blot applications. By targeting the ABHD12 protein, researchers can explore its role in various cellular processes and disease mechanisms, particularly in the fields of lipid metabolism, neurobiology, and cancer research.ABHD12, a member of the α/β-hydrolase domain-containing protein family, is known to play a crucial role in lipid metabolism and signaling cascades, making it a potential target for therapeutic interventions in metabolic disorders and cancer.
By investigating the function of ABHD12, researchers aim to uncover its potential as a biomarker or therapeutic target for conditions such as obesity, diabetes, and cancer. The ABHD12 Rabbit Polyclonal Antibody (CAB17678) enables precise detection and analysis of ABHD12, facilitating in-depth studies that may lead to novel insights and treatment strategies in relevant disease contexts.
Product Name:
ABHD12 Rabbit Polyclonal Antibody
SKU:
CAB17678
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1).
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
26090
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABHD12 Rabbit pAb (CAB17678) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
