The ABCD1 Polyclonal Antibody (CAB12141) is a valuable tool for researchers studying the ABCD1 protein, a crucial player in peroxisomal fatty acid metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the ABCD1 protein, this antibody enables precise detection and analysis in various cell types, offering researchers insights into peroxisomal function and its implications in metabolic disorders and neurodegenerative diseases.
ABCD1, also known as the adrenoleukodystrophy protein, is essential for the transportation of very long-chain fatty acids into peroxisomes for breakdown. Mutations in the ABCD1 gene result in impaired fatty acid metabolism, leading to the accumulation of toxic fatty acids and causing devastating conditions like X-linked adrenoleukodystrophy. By studying ABCD1 using this antibody, researchers can uncover new therapeutic strategies for managing peroxisomal disorders and improving patient outcomes.
Product Name:
ABCD1 Rabbit Polyclonal Antibody
SKU:
CAB12141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 340-500 of human ABCD1 (NP_000024.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
Purification Method:
Affinity purification
Gene ID:
215
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABCD1 Rabbit pAb (CAB12141) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
