The ABCA1 Polyclonal Antibody (CAB7228) is a valuable tool for researchers studying the ATP-binding cassette transporter 1 (ABCA1) protein, which plays a crucial role in cholesterol homeostasis and lipid metabolism. This antibody, developed using rabbits as the host species, exhibits high specificity and reactivity towards human samples, making it an ideal choice for Western blot applications.ABCA1 is known for its function in facilitating the efflux of cholesterol and phospholipids from cells to lipid-poor apolipoproteins, a process essential for the formation of high-density lipoprotein (HDL) particles. Dysregulation of ABCA1 has been linked to various metabolic disorders, including atherosclerosis and Tangier disease.
By targeting and detecting ABCA1 with this polyclonal antibody, researchers can gain valuable insights into the mechanisms underlying lipid metabolism and potentially identify new therapeutic targets for cardiovascular diseases.In conclusion, the ABCA1 Polyclonal Antibody (CAB7228) offers a reliable tool for investigating the role of ABCA1 in lipid transport and metabolism, providing valuable insights into the pathophysiology of metabolic disorders and informing the development of novel treatment strategies.
Product Name:
ABCA1 Rabbit Polyclonal Antibody
SKU:
CAB7228
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493.2).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
Purification Method:
Affinity purification
Gene ID:
19
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using ABCA1 Rabbit pAb (CAB7228) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
