The AARSD1 Polyclonal Antibody (PAC040482) is a valuable tool for researchers studying AARSD1, a protein involved in various biological processes, including protein translation and aminoacylation of tRNA. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.AARSD1, also known as alanyl-tRNA synthetase, plays a crucial role in protein synthesis by attaching alanine to tRNA molecules. Dysregulation of AARSD1 has been linked to various diseases, making it a potential therapeutic target for conditions such as neurodegenerative disorders and cancer.
By using the AARSD1 Polyclonal Antibody, researchers can detect and analyze AARSD1 protein levels in different cell types, aiding in the investigation of its functions and potential implications in disease pathology.Overall, the AARSD1 Polyclonal Antibody is a valuable tool for researchers interested in understanding the role of AARSD1 in various biological processes and diseases, providing insight into potential therapeutic strategies targeting this essential protein.
Western blot. All lanes: AARSD1 antibody at 0.8µg/ml. Lane 1: Hela whole cell lysate. Lane 2: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 46, 59, 66 kDa. Observed band size: 46 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40482 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO40482 at dilution of 1:100.
Background:
Functions in trans to edit the amino acid, moiety from incorrectly charged tRNA(Ala).
Synonyms:
Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1), AARSD1
UniProt Protein Function:
AARSD1: Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: LigaseChromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; nucleic acid binding; metal ion binding; ATP binding; alanine-tRNA ligase activityBiological Process: regulation of translational fidelity; alanyl-tRNA aminoacylation
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
