The AARSD1 Polyclonal Antibody (PACO07514) is a valuable tool for researchers studying AARSD1, a protein involved in mitochondrial aminoacyl-tRNA synthetase activity. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications such as Western blot and immunohistochemistry.AARSD1 plays a crucial role in protein synthesis within mitochondria and is essential for proper cell function. Dysregulation of AARSD1 has been linked to various mitochondrial disorders and neurodegenerative diseases.
By using the AARSD1 Polyclonal Antibody, researchers can detect and analyze AARSD1 protein levels in different cell types, providing valuable insights into its function and potential therapeutic implications.This antibody is a valuable tool for studies in mitochondrial biology, genetic disorders, and neurodegenerative diseases. Its high specificity and reliability make it an essential component for research exploring the role of AARSD1 in health and disease.
AARSD1: Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: LigaseChromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; nucleic acid binding; metal ion binding; ATP binding; alanine-tRNA ligase activityBiological Process: regulation of translational fidelity; alanyl-tRNA aminoacylation
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
