The AADACL2 Antibody (PAC015217) is a valuable tool for researchers studying the AADACL2 enzyme, which plays a crucial role in lipid metabolism and inflammation. This polyclonal antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the AADACL2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in lipid biology, metabolism, and inflammatory pathways.AADACL2, also known as arylacetamide deacetylase-like 2, is involved in the hydrolysis of endogenous and exogenous compounds, particularly lipid molecules.
Its role in lipid metabolism has implications for various diseases, including metabolic disorders, cardiovascular conditions, and inflammation-related diseases. Research on the function of AADACL2 is essential for developing a deeper understanding of lipid pathways and potential therapeutic targets for related disorders.Get your hands on the AADACL2 Antibody (PAC015217) today and unlock new insights into lipid metabolism and inflammatory processes in health and disease.
Antibody Name:
AADACL2 Antibody (PACO15217)
Antibody SKU:
PACO15217
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human AADACL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15217(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15217(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
AADAC is a 45 kDa membrane-associated hydrolase highly expressed in the human liver that has been implicated in the hydrolysis of arylacetamide xenobiotics including flutamide and phenacetin.556–560AADAC is highly homologous to several related lipases, AADACL1, 2, and 4, the latter two of which remain completely unannotated. Overexpression of AADAC in a rat hepatoma cell line produces changes in cellular TG levels, apoplipoprotein B secretion, and fatty acid, oxidation, but the mechanism for these effects remains unclear.561 Candidate endogenous substrates, selective inhibitors, or knockout mice have not, to our knowledge, been described for AADAC or the related enzymes AADACL2 and AADACL4.
Synonyms:
arylacetamide deacetylase-like 2
UniProt Protein Function:
AADACL2: Belongs to the 'GDXG' lipolytic enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Hydrolase; Secreted; EC 3.1.1.-Chromosomal Location of Human Ortholog: 3q25.1
