The 4-1BB (CD137) Monoclonal Antibody is a key tool for research involving the CD137 protein, a member of the tumor necrosis factor receptor superfamily. This antibody, produced through hybridoma technology, is highly specific to human CD137 and has been validated for use in various applications, including Western blot and immunohistochemistry.CD137 plays a crucial role in the regulation of immune responses, particularly in the activation and expansion of T cells. Its expression is upregulated on activated T cells, making it a valuable marker for monitoring immune activation and identifying potential therapeutic targets for diseases such as cancer, autoimmune disorders, and infectious diseases.
By using the 4-1BB (CD137) Monoclonal Antibody, researchers can effectively detect and analyze CD137 expression in different cell types, providing insights into its function in immune regulation and its potential as a target for immunotherapy. This antibody is an essential tool for studies in immunology, oncology, and other fields where understanding CD137's role in immune responses is critical.
Product Name:
4-1BB/CD137 Monoclonal Antibody
SKU:
CAB22167
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-186 of human 4-1BB/CD137 (NP_001552.2).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Purification Method:
Affinity purification
Gene ID:
3604
Clone Number:
ARC55368
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with 4-1BB/CD137 using 4-1BB/CD137 Rabbit mAb (CAB22167) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
