UPF3A Rabbit Polyclonal Antibody (CAB15893)
- SKU:
- CAB15893
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | UPF3A Rabbit Polyclonal Antibody |
SKU: | CAB15893 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 327-476 of human UPF3A (NP_075387.1). |
Sequence: | EGSL EEPQ ETSH SGSD KEHR DVER SQEQ ESEA QRYH VDDG RRHR AHHE PERL SRRS EDEQ RWGK GPGQ DRGK KGSQ DSGA PGEA MERL GRAQ RCDD SPAP RKER LANK DRPA LQLY DPGA RFRA RECG GNRR ICKA EGSG TGPE KREE AE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | UPF3; HUPF3A; RENT3A; UPF3A |
Positive Sample: | Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 55kDa |
Observed MW: | 55kDa |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 65110 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |