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UBB/UBC/RPS27A/UBA52 Antibody (PACO01667)

SKU:
PACO01667
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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UBB/UBC/RPS27A/UBA52 Antibody (PACO01667)

The UBB/UBC/RPS27A/UBA52 Antibody (PACO01667) is a polyclonal antibody designed for research involving the ubiquitin proteins UBB, UBC, RPS27A, and UBA52. These proteins play essential roles in the ubiquitin-proteasome pathway, which is crucial for protein degradation and regulation in cells. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. It specifically binds to the UBB, UBC, RPS27A, and UBA52 proteins, allowing for the detection and analysis of these important components in various cell types.The ubiquitin-proteasome pathway is involved in many cellular processes, including cell cycle regulation, DNA repair, and immune response.

Dysregulation of this pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. Understanding the roles of UBB, UBC, RPS27A, and UBA52 in this pathway is essential for advancing research into these diseases and developing targeted therapies.For researchers studying protein degradation, cell signaling, and disease mechanisms, the UBB/UBC/RPS27A/UBA52 Antibody (PACO01667) is a valuable tool for their studies in immunology, cancer research, and beyond.

Antibody Name:UBB/UBC/RPS27A/UBA52 Antibody
Antibody SKU:PACO01667
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human Ub.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:UBB; Polyubiquitin-B; UBC; Polyubiquitin-C; RPS27A; UBA80; UBCEP1; Ubiquitin-40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80; UBA52; UBCEP2; Ubiquitin-60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal pr
UniProt Protein Function:UBB: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Belongs to the ubiquitin family.
UniProt Protein Details:

Protein type:Apoptosis; Ubiquitin-like modifier; Cell development/differentiation; Cell cycle regulation; Transcription regulation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p12-p11.2

Cellular Component: nucleoplasm; neuron projection; cell soma; mitochondrion; plasma membrane; endosome membrane; cytosol

Molecular Function:protein binding

Biological Process: circadian rhythm; I-kappaB kinase/NF-kappaB cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of apoptosis; activation of MAPK activity; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; endosome transport; T cell receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of NF-kappaB transcription factor; mitochondrion transport along microtubule; regulation of apoptosis; toll-like receptor 5 signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; regulation of mitochondrial membrane potential; transforming growth factor beta receptor signaling pathway; JNK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; G2/M transition of mitotic cell cycle; toll-like receptor 4 signaling pathway; regulation of interferon type I production; glycogen biosynthetic process; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; glucose metabolic process; Notch receptor processing; virus assembly; toll-like receptor 2 signaling pathway; carbohydrate metabolic process; viral protein processing; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of interferon type I production; negative regulation of apoptosis; G1/S transition of mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of epidermal growth factor receptor signaling pathway; apoptosis; pathogenesis; negative regulation of transcription from RNA polymerase II promoter; viral infectious cycle; toll-like receptor 10 signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of interferon type I production; transmembrane transport; epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; DNA repair; MyD88-dependent toll-like receptor signaling pathway; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; toll-like receptor signaling pathway; innate immune response; gene expression; mitotic cell cycle; negative regulation of transforming growth factor beta receptor signaling pathway; neurite morphogenesis

Disease: Cleft Palate, Isolated

NCBI Summary:This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Code:P0CG47
NCBI GenInfo Identifier:302595875
NCBI Gene ID:7314
NCBI Accession:P0CG47.1
UniProt Secondary Accession:P0CG47,P0CG48, P62979, P62987,
UniProt Related Accession:P0CG47
Molecular Weight:
NCBI Full Name:Polyubiquitin-B
NCBI Synonym Full Names:ubiquitin B
NCBI Official Symbol:UBB  
NCBI Official Synonym Symbols:HEL-S-50  
NCBI Protein Information:polyubiquitin-B
UniProt Protein Name:Polyubiquitin-B
Protein Family:Ubiquilin
UniProt Gene Name:UBB  
UniProt Entry Name:UBB_HUMAN

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