The TETX Antibody (PAC034670) is a highly specific and sensitive tool for studying TETX, a crucial enzyme involved in DNA demethylation. This polyclonal antibody, produced and validated for use in various research applications, is ideal for investigating the role of TETX in epigenetic regulation and its impact on gene expression.TETX is known to play a significant role in the process of DNA demethylation, a key mechanism in regulating gene expression and cellular function. Dysregulation of TETX activity has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.
This antibody, developed using advanced technology and validated for specificity and sensitivity, offers researchers a reliable tool for detecting and analyzing TETX protein levels in different cell types and tissues. Its high affinity and reactivity with human samples make it a valuable asset for studies in epigenetics, cancer biology, and other fields where TETX is a central focus of investigation.
Antibody Name:
tetX Antibody (PACO34670)
Antibody SKU:
PACO34670
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Clostridium tetani
Immunogen:
Recombinant Clostridium tetani Tetanus toxin protein (123-573AA)
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln- |-Phe-77' bond of synaptobrevin-2.
Function: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.Catalytic activity: Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2.Cofactor: Binds 1 zinc ion per subunit By similarity.Subunit structure: The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Miscellaneous: The C-terminus of the heavy chain binds to ganglioside receptors.Sequence similarities: Belongs to the peptidase M27 family.
