The SLC6A2 Polyclonal Antibody (CAB1421) is a valuable tool for researchers studying the SLC6A2 protein, also known as the norepinephrine transporter. This antibody, generated from rabbit immunization, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the SLC6A2 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for research in neuroscience, endocrinology, and cardiovascular biology.
SLC6A2 plays a crucial role in the reuptake of norepinephrine, a neurotransmitter involved in the regulation of mood, stress response, and cardiovascular function. Dysregulation of SLC6A2 has been linked to disorders such as depression, anxiety, and hypertension, making it a promising target for therapeutic intervention. By studying the function and expression of SLC6A2, researchers can gain insights into the pathophysiology of these conditions and develop novel treatment strategies.
Product Name:
SLC6A2 Rabbit Polyclonal Antibody
SKU:
CAB1421
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human SLC6A2 (NP_478066.3).
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Purification Method:
Affinity purification
Gene ID:
6530
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC6A2 antibody (CAB1421) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
