The SLC25A1 Polyclonal Antibody (CAB10247) is a powerful tool for studying SLC25A1, a crucial protein involved in mitochondrial metabolism and energy production. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for Western blot applications. By binding to the SLC25A1 protein, researchers can accurately detect and analyze its expression levels in various cell types, facilitating investigations in the fields of metabolism, bioenergetics, and cancer research.SLC25A1, also known as the citrate transporter protein, is essential for transporting citrate across the mitochondrial membrane, a key step in the citric acid cycle and fatty acid synthesis.
Dysregulation of SLC25A1 has been linked to metabolic disorders, neurodegenerative diseases, and various cancers, highlighting its importance in cellular metabolism and homeostasis. By studying the function and regulation of SLC25A1, researchers can gain insights into mitochondrial dysfunction and potential therapeutic targets for metabolic diseases and cancer treatment.
Product Name:
SLC25A1 Rabbit Polyclonal Antibody
SKU:
CAB10247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human SLC25A1 (NP_005975.1).
This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6576
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC25A1 Rabbit pAb (CAB10247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
