SIRT1 Polyclonal Antibody (CAB21418)
- SKU:
- CAB21418
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | SIRT1 Polyclonal Antibody |
SKU: | CAB21418 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SIRT1 (NP_036370.2). |
Sequence: | TILK DLLP ETIP PPEL DDMT LWQI VINI LSEP PKRK KRKD INTI EDAV KLLQ ECKK IIVL TGAG VSVS CGIP DFRS RDGI YARL AVDF PDLP DPQA MFDI E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | SIR2; SIR2L1; SIR2alpha; SIRT1 |
Positive Sample: | 293T,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Nucleus, Nucleus, PML body. |
Calculated MW: | 82kDa |
Observed MW: | 120KD |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 23411 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |