The RYR2 Polyclonal Antibody (CAB0298) is a specialized research tool for scientists studying the Ryanodine Receptor 2 (RYR2) protein, an essential component of calcium signaling in muscle cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable tool for Western blot applications.RYR2 is a key player in the regulation of intracellular calcium release, particularly in cardiac muscle cells. Dysregulation of RYR2 has been linked to various cardiovascular diseases, including arrhythmias and heart failure.
The ability to detect and analyze RYR2 protein levels in different cell types with this antibody provides researchers with valuable insights into its role in cardiac function and disease pathogenesis.Research on RYR2 is crucial in understanding and potentially treating cardiac disorders, making the RYR2 Polyclonal Antibody a valuable tool in cardiovascular research. By uncovering the mechanisms involving RYR2, scientists can develop targeted therapies aimed at correcting calcium signaling abnormalities and improving cardiac function.
Product Name:
RYR2 Rabbit Polyclonal Antibody
SKU:
CAB0298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 4868-4967 of human RYR2 (NP_001026.2).
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.
Purification Method:
Affinity purification
Gene ID:
6262
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using RYR2 Rabbit pAb (CAB0298) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
