The Phospho-MAPT (T212) Polyclonal Antibody (CABP0400) is a valuable tool for researchers studying the MAPT protein, which is involved in regulating microtubule dynamics and neuronal signaling. This antibody, developed using rabbits as the host species, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically targeting the phosphorylated form of MAPT at threonine 212, this antibody allows for the detection and analysis of MAPT in various cell types, making it an excellent choice for studies in neuroscience and neurodegenerative diseases.MAPT, also known as tau protein, plays a crucial role in stabilizing microtubules and facilitating intracellular transport within neurons.
Abnormal phosphorylation of MAPT at threonine 212 has been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Research into the regulation and function of phosphorylated MAPT is essential for understanding the mechanisms underlying these devastating conditions and developing targeted therapies to combat them. The Phospho-MAPT (T212) Polyclonal Antibody provides a valuable tool for investigating the role of MAPT in health and disease, offering new insights into potential treatment strategies for neurodegenerative disorders.
Product Name:
Phospho-Tau-T212 Polyclonal Antibody
SKU:
CABP0400
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding T212 of human Tau
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of HeLa, using Phospho-Tau-T212 antibody (CABP0400) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
