The Phospho-Histone H1 (Thr3) Antibody (PACO00167) is a valuable tool for researchers studying histone modifications and their role in chromatin structure and function. This antibody, raised in rabbits, specifically targets the phosphorylated form of Histone H1 at Threonine 3, a post-translational modification with important implications in gene regulation and cellular processes.Histone H1 is a key component of chromatin, the complex of DNA and proteins that packages and organizes the genome within the nucleus. Phosphorylation of Histone H1 at Thr3 has been linked to transcriptional activation and chromatin remodeling, making it a marker of active gene expression.
Research suggests that this modification may play a role in cell cycle regulation, DNA repair, and other critical biological processes.The Phospho-Histone H1 (Thr3) Antibody is validated for use in various applications, including Western blotting and immunofluorescence, allowing for the detection and analysis of phosphorylated Histone H1 in different cell types and experimental settings. Its specificity and reliability make it a valuable tool for studies in epigenetics, gene regulation, and cancer research, providing insights into the dynamic and intricate mechanisms that govern chromatin structure and function.
Antibody Name:
Phospho-Histone H1 (Thr3) Antibody
Antibody SKU:
PACO00167
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB
Recommended Dilutions:
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
