ATM Rabbit Polyclonal Antibody (CAB15645)
- SKU:
- CAB15645
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | ATM Rabbit Polyclonal Antibody |
SKU: | CAB15645 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2320-2566 of ATM (NP_000042.3). |
Sequence: | DASC AANN PSLK LTYT ECLR VCGN WLAE TCLE NPAV IMQT YLEK AVEV AGNY DGES SDEL RNGK MKAF LSLA RFSD TQYQ RIEN YMKS SEFE NKQA LLKR AKEE VGLL REHK IQTN RYTV KVQR ELEL DELA LRAL KEDR KRFL CKAV ENYI NCLL SGEE HDMW VFRL CSLW LENS GVSE VNGM MKRD GMKI PTYK FLPL MYQL AARM GTKM MGGL GFHE VLNN LISR ISMD HPHH TLFI ILAL ANA |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; ATM |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Nucleus. |
Calculated MW: | 351kDa |
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Purification Method: | Affinity purification |
Gene ID: | 472 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |