PDHB Rabbit Monoclonal Antibody (CAB4645)
- SKU:
- CAB4645
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PDHBD
- PDHE1-B
- PHE1B
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | PDHB Rabbit Monoclonal Antibody |
SKU: | CAB4645 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 260-359 of human Pyruvate Dehydrogenase E1 beta subunit (P11177). |
Sequence: | GVEC EVIN MRTI RPMD METI EASV MKTN HLVT VEGG WPQF GVGA EICA RIME GPAF NFLD APAV RVTG ADVP MPYA KILE DNSI PQVK DIIF AIKK TLNI |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | PDHBD; PHE1B; E1beta; PDHE1B; PDHE1-B; PDHB |
Positive Sample: | 293T,K-562,U-251MG,Mouse liver,Mouse skeletal muscle,Mouse heart,Rat skeletal muscle,Rat kidney,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 39kDa |
Observed MW: | 34kDa |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5162 |
Clone Number: | ARC1074 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |