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FITC Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1802)

SKU:
AGEL1802
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
G043H7
Conjugation:
FITC
€179 - €569
Frequently bought together:

Description

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FITC Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody (FITC Conjugated) is a cutting-edge tool designed for immunological research, particularly focusing on the CD197 protein, which plays a vital role in immune cell trafficking and migration. This monoclonal antibody, conjugated with FITC for fluorescent detection, is specifically engineered for use in flow cytometry and immunofluorescence applications.CD197, also known as CCR7, is a chemokine receptor expressed on various immune cell types, including T cells and dendritic cells, and is instrumental in facilitating their proper homing to lymphoid tissues. This antibody's high specificity and affinity for human CD197 make it an invaluable resource for investigating immune cell movement and lymphoid organ development processes.

By utilizing this antibody, researchers can gain insight into the intricate mechanisms underlying immune cell migration and their impact on immune responses in health and disease. The ability to accurately detect and analyze CD197 expression in different cell populations opens up new avenues for studying immune system dynamics, inflammation, and potentially developing targeted therapies for conditions where immune cell trafficking is dysregulated.In summary, the Human CD197 (CCR7) Monoclonal Antibody (FITC Conjugated) is a sophisticated research tool that holds promise for advancing our understanding of immune cell behavior and its implications for various physiological and pathological processes.

Product Title:FITC Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1802
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:FITC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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