HNMT Rabbit Polyclonal Antibody (CAB13499)
- SKU:
- CAB13499
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | HNMT Rabbit Polyclonal Antibody |
SKU: | CAB13499 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human HNMT (NP_008826.1). |
Sequence: | MASS MRSL FSDH GKYV ESFR RFLN HSTE HQCM QEFM DKKL PGII GRIG DTKS EIKI LSIG GGAG EIDL QILS KVQA QYPG VCIN NEVV EPSA EQIA KYKE LVAK TSNL ENVK FAWH KETS SEYQ SRML EKKE LQKW DFIH MIQM LYYV KDIP ATLK FFHS LLGT NAKM LIIV VSGS SGWD KLWK KYGS RFPQ DDLC QYIT SDDL TQML DNLG LKYE CYDL LSTM DISD CFID GNEN GDLL WDFL TETC NFNA TAPP DLRA ELGK DLQE PEFS AKKE GKVL FNNT LSFI VIEA |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HMT; MRT51; HNMT-S1; HNMT-S2; HNMT |
Positive Sample: | HT-29,HepG2,HeLa,Mouse liver,Mouse kidney,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 33kDa |
Observed MW: | 33kDa |
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3176 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |