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Anti-GRASP65 Antibody (CAB2316)

SKU:
CAB2316
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GOLPH5
GRASP65
P65
Research Area:
Cell Biology
€139 - €419
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Description

Anti-GRASP65 Antibody (CAB2316)

The Anti-GRASP65 Antibody (CAB2316) is a high-quality research tool designed for the study of GRASP65, a Golgi reassembly stacking protein involved in membrane trafficking and protein sorting processes. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.GRASP65 plays a critical role in maintaining the structural integrity of the Golgi apparatus and facilitating the proper sorting and trafficking of proteins to their respective destinations within the cell.

Dysregulation of GRASP65 function has been implicated in various diseases, including cancer and neurological disorders.By specifically targeting the GRASP65 protein, this antibody enables researchers to detect and analyze GRASP65 expression in different cell types, providing valuable insights into its function and potential implications in disease pathogenesis. Its versatility and reliability make it an ideal tool for investigations in cell biology, molecular biology, and disease mechanism studies.

Product Name:GRASP65 Rabbit mAb
Product Code:CAB2316
Size:20uL, 50uL, 100uL
Synonyms:GOLPH5, GRASP65, P65
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GRASP65
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human GRASP65
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64689
Uniprot:Q9BQQ3
Calculated MW:65kDa
Observed MW:70kDa
UniProt Protein Function:GRASP65: Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes. Belongs to the GORASP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 3p22-p21.33

Cellular Component: Golgi membrane; Golgi apparatus

Biological Process: protein transport; negative regulation of dendrite morphogenesis; mitotic cell cycle; Golgi organization and biogenesis

NCBI Summary:The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Code:Q9BQQ3
NCBI GenInfo Identifier:51316077
NCBI Gene ID:64689
NCBI Accession:Q9BQQ3.3
UniProt Related Accession:Q9BQQ3
Molecular Weight:
NCBI Full Name:Golgi reassembly-stacking protein 1
NCBI Synonym Full Names:golgi reassembly stacking protein 1
NCBI Official Symbol:GORASP1  
NCBI Official Synonym Symbols:P65; GOLPH5; GRASP65  
NCBI Protein Information:Golgi reassembly-stacking protein 1
UniProt Protein Name:Golgi reassembly-stacking protein 1
UniProt Synonym Protein Names:Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; GOLPH5; Golgi reassembly-stacking protein of 65 kDa; GRASP65
UniProt Gene Name:GORASP1  
UniProt Entry Name:GORS1_HUMAN

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