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Glutaredoxin 1 (GLRX) Monoclonal Antibody (CAB23246)

SKU:
CAB23246
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Glutaredoxin 1 (GLRX) Monoclonal Antibody
SKU:CAB23246
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 11-106 of human Glutaredoxin 1 (GLRX) (NP_002055.1).
Sequence:QPGK VVVF IKPT CPYC RRAQ EILS QLPI KQGL LEFV DITA TNHT NEIQ DYLQ QLTG ARTV PRVF IGKD CIGG CSDL VSLQ QSGE LLTR LKQI GALQ
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:GRX; GRX1; Glutaredoxin 1 (GLRX)
Positive Sample:Jurkat, Mouse liver, Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cytoplasm
Calculated MW:12kDa
Observed MW:12kDa

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Purification Method:Affinity purification
Gene ID:2745
Clone Number:ARC59054
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using Glutaredoxin 1（GLRX） Rabbit mAb (CAB23246) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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