The Frizzled 3 Polyclonal Antibody (CAB10063) is a crucial tool for researchers studying the Frizzled 3 protein, a key player in the Wnt signaling pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the Frizzled 3 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in developmental biology, cancer research, and regenerative medicine.
Frizzled 3 is a transmembrane receptor involved in cell signaling pathways that regulate cell proliferation, differentiation, and migration. Dysregulation of Frizzled 3 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. Research on the role of Frizzled 3 is crucial for unraveling its complex functions and developing targeted therapies to modulate its activity in disease contexts.
Product Name:
FZD3 Rabbit Polyclonal Antibody
SKU:
CAB10063
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-205 of human FZD3 (NP_059108.1).
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia.
Purification Method:
Affinity purification
Gene ID:
7976
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat brain, using FZD3 Rabbit pAb (CAB10063) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
