The CPT2 Polyclonal Antibody (CAB12426) is a valuable tool for researchers studying carnitine palmitoyltransferase II (CPT2), an enzyme involved in fatty acid metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By targeting the CPT2 protein, this antibody enables precise detection and analysis in various cell types, making it an excellent choice for investigations in metabolic disorders, mitochondrial diseases, and lipid metabolism research.
CPT2 serves a critical role in mitochondrial beta-oxidation, the process by which fatty acids are broken down for energy production. Dysregulation of CPT2 activity is associated with numerous metabolic disorders, including carnitine palmitoyltransferase II deficiency, which can lead to severe symptoms such as muscle weakness, liver dysfunction, and hypoglycemia. Research into the function and regulation of CPT2 is crucial for developing potential therapies for these conditions and expanding our understanding of fatty acid metabolism.
Product Name:
CPT2 Rabbit Polyclonal Antibody
SKU:
CAB12426
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 404-658 of human CPT2 (NP_000089.1).
The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
Purification Method:
Affinity purification
Gene ID:
1376
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CPT2 Rabbit pAb (CAB12426) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
