The CES3 Polyclonal Antibody (CAB4558) is a valuable tool for researchers studying carboxylesterase 3 (CES3), an enzyme involved in drug metabolism and lipid metabolism. This antibody, produced in rabbits, has been shown to be highly specific for human samples, making it an ideal choice for Western blot applications. By binding to CES3, the antibody allows for accurate detection and analysis of the enzyme in various cell types.CES3 is known to play a crucial role in the metabolism of a wide range of drugs and lipids, making it an important target for drug development and personalized medicine approaches.
Research into the function of CES3 is essential for understanding how drugs are processed in the body and how variations in CES3 activity may impact drug efficacy and toxicity.By using the CES3 Polyclonal Antibody, researchers can gain valuable insights into the role of CES3 in drug metabolism, lipid metabolism, and potential implications for personalized medicine approaches. This antibody is a valuable tool for studies in pharmacology, toxicology, and drug development, offering researchers a reliable way to investigate the function of CES3 in various biological contexts.
Product Name:
CES3 Rabbit Polyclonal Antibody
SKU:
CAB4558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1).
LO2,HT-29,Mouse small intestine,Mouse large intestine,Rat liver,Rat small intestine
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum lumen.
Calculated MW:
62kDa
Observed MW:
62kDa
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.
Purification Method:
Affinity purification
Gene ID:
23491
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CES3 Rabbit pAb (CAB4558) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
