Caspase-3 Rabbit Polyclonal Antibody (CAB11319)
- SKU:
- CAB11319
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Caspase-3 Rabbit Polyclonal Antibody |
SKU: | CAB11319 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 6-105 of human Caspase-3 (NP_004337.2). |
Sequence: | NSVD SKSI KNLE PKII HGSE SMDS GISL DNSY KMDY PEMG LCII INNK NFHK STGM TSRS GTDV DAAN LRET FRNL KYEV RNKN DLTR EEIV ELMR DVSK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:100 - 1:500 |
Synonyms: | CPP32; SCA-1; CPP32B; Caspase-3 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 32kDa |
Observed MW: | 17kDa/19kDa/32kDa |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Purification Method: | Affinity purification |
Gene ID: | 836 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |