The ATP6V0A2 Polyclonal Antibody (PAC042834) is a valuable tool for research involving ATP6V0A2, a subunit of the V-ATPase complex that plays a critical role in regulating pH levels within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications. By binding specifically to the ATP6V0A2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it well-suited for investigations in cell biology and cancer research.
ATP6V0A2 is a key component of the V-ATPase proton pump, which is essential for maintaining cellular pH balance and supporting various physiological processes, including endocytosis, lysosomal function, and autophagy. Dysregulation of ATP6V0A2 has been implicated in a range of diseases, such as cancer, neurodegenerative disorders, and osteopetrosis. Therefore, exploring the mechanisms underlying ATP6V0A2 function is crucial for developing targeted therapies and understanding disease pathogenesis.
Antibody Name:
ATP6V0A2 Antibody (PACO42834)
Antibody SKU:
PACO42834
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA)
Immunofluorescent analysis of A431 cells using PACO42834 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]
