The ASMT Polyclonal Antibody (CAB11840) is a valuable tool for researchers studying ASMT, a key enzyme involved in melatonin biosynthesis. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in Western blot applications. By binding to the ASMT protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential component of studies in chronobiology, neurology, and sleep research.
ASMT, also known as acetylserotonin O-methyltransferase, is crucial for the synthesis of melatonin, a hormone that regulates the sleep-wake cycle and other biological rhythms. Dysregulation of ASMT has been linked to sleep disorders, mood disorders, and other conditions affecting circadian rhythm. Research into ASMT function is vital for understanding these disorders and developing new therapies for improving sleep quality and mental health.
Product Name:
ASMT Rabbit Polyclonal Antibody
SKU:
CAB11840
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 76-298 of human ASMT (NP_001164510.1).
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
438
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293 cells, using ASMT Rabbit pAb (CAB11840).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
