The Anti-HIST1H1C Antibody (CAB3299) is a valuable tool for researchers studying histone proteins and their role in chromatin structure and gene regulation. This polyclonal antibody is raised in rabbits and is highly specific for HIST1H1C in human samples. Validated for use in Western blot applications, this antibody binds specifically to the HIST1H1C protein, allowing for accurate detection and analysis in a variety of cell types.HIST1H1C, a member of the histone H1 family, plays a crucial role in DNA packaging and gene expression regulation. Dysregulation of histone proteins like HIST1H1C has been implicated in various diseases, including cancer and autoimmune disorders.
By studying the function and expression of HIST1H1C, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.With its high reactivity and specificity, the Anti-HIST1H1C Antibody (CAB3299) is an essential tool for researchers investigating the role of histone proteins in health and disease. Its use in Western blot applications allows for accurate and reliable detection of HIST1H1C, making it an ideal choice for studies in molecular biology, genetics, and epigenetics.
Product Name:
HIST1H1C Rabbit Polyclonal Antibody
SKU:
CAB3299
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIST1H1C (NP_005310.1).
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Purification Method:
Affinity purification
Gene ID:
3006
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using HIST1H1C Rabbit pAb (CAB3299) at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
