Blog

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II interferon and activating macrophages. It's produced as an inactive form and activated by caspase-1, signaling through IL-18 receptors to trigger inflammation. IL-18's regulation involves IL-18 binding protein (IL-18BP) and IL-37, which modulate its activity and prevent excessive inflammation. It contributes to T cell differentiation and NK cell cytotoxicity, influencing various immune functions. IL-18 is implicated in several diseases, including Crohn's disease and sepsis, making it a potential …