Blog
Ifabotuzumab Biosimilar: Advancing EGFRvIII-Targeted Cancer Therapy
Ifabotuzumab is a monoclonal antibody targeting the EGFRvIII mutation, a tumor-specific variant of the epidermal growth factor receptor (EGFR). This mutation is associated with aggressive
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7th Dec 2024
Gemtuzumab Biosimilar: Advancing CD33-Targeted Therapy for AML
Gemtuzumab ozogamicin is a CD33-targeting antibody-drug conjugate (ADC) approved for the treatment of acute myeloid leukemia (AML). By selectively delivering a cytotoxic payload to CD33-p
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5th Dec 2024
Biosimilar: Expanding Access to Monoclonal Antibody-Based Therapies
1. What is a Biosimilar? A biosimilar is a biologic medical product that is highly similar to an already-approved reference biologic. While minor differences in clinically inactive c
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5th Dec 2024
Elotuzumab Biosimilar: A New Frontier in Multiple Myeloma Treatment
Elotuzumab is a monoclonal antibody that targets SLAMF7 (signaling lymphocytic activation molecule F7), a protein highly expressed on multiple myeloma (MM) cells and natural killer (NK) c
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26th Nov 2024
Amino Acids: Functions, Roles, and Structures
Amino acids are the fundamental units of proteins, playing critical roles in virtually every biological process. Composed of a central carbon atom bonded to an amino group (-NHâ‚‚), a carbo
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22nd Nov 2024
MHC Class I vs MHC Class II: Key Differences and Functions
Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immun
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22nd Nov 2024
Boiling Proteins for Western Blotting: Optimal Conditions and Best Practices
Boiling proteins is a critical step in preparing samples for Western blotting, a technique widely used to detect specific proteins in complex mixtures. Proper heating denatures the protei
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20th Nov 2024
Immunoglobulins: Structure, Function, and Clinical Importance
Immunoglobulins (Igs), also known as antibodies, are glycoproteins produced by B cells and plasma cells. They play a central role in the immune system by identifying and neutralizing path
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20th Nov 2024
Clinical Pathology Labs List: Overview, Services, and Importance
Clinical pathology labs play a crucial role in modern healthcare, providing critical diagnostic testing services for a wide array of diseases and conditions. These laboratories are design
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19th Nov 2024
Phosphorothioate: Enhancing Stability in Oligonucleotide-Based Therapies
Phosphorothioate is a chemical modification commonly used in oligonucleotide-based therapies to enhance the stability and efficacy of therapeutic nucleic acids. In this modification, one
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15th Nov 2024
M2 Supplement for Organoid Cell Culture: Enhancing Growth and Differentiation
The use of M2 Supplement in organoid culture has revolutionized the way researchers cultivate and maintain these three-dimensional (3D) cellular models. Organoids—self-organizing cell clu
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12th Nov 2024
Typical Workflow of CRISPR-Cas9 Genome Editing
The CRISPR-Cas9 system is a powerful tool for genome editing, enabling precise modifications to DNA. The typical CRISPR-Cas9 workflow involves several steps, from designing guide RNAs to
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6th Nov 2024
Freezing Stimulated T Cells: A Detailed Guide
Cryopreservation of stimulated T cells is a common technique in immunology research, allowing for long-term storage while maintaining their functional viability. Stimulated T cells—especi
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6th Nov 2024
Excluding Doublets in FACS Analysis: A Comprehensive Guide
Overview: Doublet discrimination is essential in Fluorescence-Activated Cell Sorting (FACS) to ensure accurate results, as doublets (two cells sticking together) can resemble single cells
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5th Nov 2024
Flow Cytometry Gating: A Comprehensive Guide
Flow cytometry gating is a critical step for isolating and analyzing specific cell populations based on size, granularity, and fluorescence. Proper gating strategies enhance data accuracy
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5th Nov 2024
Passaging Hybridoma Cells: A Detailed Guide
Hybridoma cells are essential tools for producing monoclonal antibodies and are derived by fusing B lymphocytes (antibody-producing cells) with myeloma cells (cancer cells) to achieve bot
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5th Nov 2024
Growth Factors Can Cooperate to Promote Tumorigenesis
Introduction Tumorigenesis, the process by which normal cells transform into cancer cells, is a multifaceted and complex event influenced by various internal and external factors. Among the
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3rd May 2024
Inflammasome Activation Pathways: A Comprehensive Overview
Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical step
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29th Apr 2024
Illuminating the Multifaceted Role of Acetylation: Bridging Chemistry and Biology Introduction:
Acetylation, a chemical process characterized by the addition of an acetyl functional group to a molecule, stands as a cornerstone in both biochemical and biological landscapes. Its significanc
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16th Apr 2024
Innate Immune System Cells: An In-depth Overview
The innate immune system is the first line of defense against pathogens, providing a rapid response to infections. This system comprises various cell types, each with specialized roles in detectin
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28th Mar 2024
Mitophagy: The Cell's Cleanup Crew for Healthy Living
Mitophagy, a term derived from the fusion of "mitochondria" and "autophagy," represents a vital cellular process responsible for the targeted degradation and recycling of dysfunctional mitochon
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26th Mar 2024
Navigating Cell Culture Supplements: Fetal Bovine Serum vs. Horse Serum in Biomedical Research
The choice of appropriate cell culture supplements emerges as a crucial factor in ensuring the efficacy and consistency of experimental results. Among the various options available, two commonl
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25th Mar 2024
How to Thaw Cells: Best Practices for Cell Culture Success
Cell culture techniques are fundamental to biomedical research, providing crucial insights into cellular functions, drug discovery, and disease mechanisms. A critical step in cell culture is the p
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19th Mar 2024
Sodium and Potassium Indicators and Ionophores: A Comprehensive Insight
Understanding the dynamics of sodium and potassium ions within biological systems is crucial for deciphering cellular processes and developing therapeutic strategies. Sodium and potassium indicato
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18th Mar 2024