Blog
Iscalimab: Advancing Research in Autoimmune Diseases and Transplantation
Iscalimab (CFZ533) is a monoclonal antibody targeting CD40, a key receptor in the immune system. By blocking CD40-CD40L interactions, Iscalimab inhibits immune activation, making it a pro
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12th Jan 2025
Varlilumab: Unlocking CD27’s Potential in Cancer Research
Varlilumab is a monoclonal antibody targeting CD27, a critical costimulatory receptor in the immune system. Acting as a CD27 agonist, Varlilumab enhances T-cell activation and effector fu
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12th Jan 2025
MHC Class I vs MHC Class II: Key Differences and Functions
Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immun
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22nd Nov 2024
Freezing Stimulated T Cells: A Detailed Guide
Cryopreservation of stimulated T cells is a common technique in immunology research, allowing for long-term storage while maintaining their functional viability. Stimulated T cells—especi
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6th Nov 2024
FoxP3: Understanding Regulatory T Cell Control in Tumor Immunity
Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a speciali
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30th Oct 2024
CD86: Enhancing T Cell Activation in Immunotherapy
Introduction to CD86 and Its Role in Immune Activation CD86 is a crucial co-stimulatory molecule that plays an essential role in T cell activation, driving the immune system’s abilit
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23rd Oct 2024
SLAMF7: Activating Natural Killer Cells for Potent Anti-Cancer Responses
Introduction to SLAMF7 in Cancer Immunotherapy SLAMF7, also known as Signaling Lymphocytic Activation Molecule F7, is a surface receptor found on natural killer (NK) cells, T cells,
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16th Oct 2024
CD122: Fine-Tuning T Cell Responses in Immunotherapy
Introduction to CD122 in Immunotherapy CD122, also known as the interleukin-2 receptor beta chain (IL-2Rβ), is a critical component of the immune system's response to pathogens and m
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15th Oct 2024
TNFR2: Taming Regulatory T Cells to Enhance Anti-Tumor Immunity
In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly regu
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14th Oct 2024
PVR: Balancing Immune Activation and Suppression in Cancer
PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a r
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10th Oct 2024
CD28: Amplifying T Cell Responses for Better Tumor Clearance
The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecules
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10th Oct 2024
SIRPα Inhibition: Clearing Tumors by Promoting Phagocytosis
Cancer cells are adept at avoiding destruction by the immune system, often exploiting specific pathways to escape detection and elimination. One of these key mechanisms involves the SIRPα
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8th Oct 2024
Harnessing CD40 for Potent Anti-Tumor Immune Responses
CD40, a member of the tumor necrosis factor receptor (TNFR) superfamily, plays a pivotal role in regulating immune responses, particularly in activating antigen-presenting cells (APCs) an
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4th Oct 2024
Targeting VISTA: Unleashing the Power of T Cells in Cancer Therapy
V-domain Ig suppressor of T cell activation (VISTA) is an emerging immune checkpoint receptor that plays a key role in suppressing T cell activity within the tumor microenvironment (TME).
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3rd Oct 2024
TIM-3: Targeting T Cell Exhaustion for Better Immunotherapy Outcomes
T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to ef
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3rd Oct 2024
GITR: Boosting T Cell Activation for Enhanced Cancer Immunotherapy
Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GITR
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3rd Oct 2024
CD25 and Tregs: Understanding the Role of Regulatory T Cells in Tumor Immunity
Regulatory T cells (Tregs) play a crucial role in maintaining immune balance by suppressing excessive immune responses that could lead to tissue damage. However, in the context of cancer,
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3rd Oct 2024
NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy
Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill cance
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3rd Oct 2024
LAG-3: Revitalizing T Cells in Exhaustion for Combination Therapies
Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target fo
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2nd Oct 2024
CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells
CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Helpe
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25th Sep 2024
Anti-PD-1: Restoring T Cell Function in Cancer Immunotherapy
Cancer immunotherapy has revolutionized the treatment landscape for various malignancies. One of the most promising therapeutic strategies is the use of immune checkpoint inhibitors, part
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24th Sep 2024
Anti-CTLA-4: Unleashing the Power of T Cells in Combination Immunotherapy
Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to fight malignancies. Among the notable advancements in this field is the development of immune c
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24th Sep 2024
CD8+ T Cells: Understanding the Role of Cytotoxic T Cells in Immunity
CD8+ T cells, also known as cytotoxic T lymphocytes (CTLs), are a critical component of the immune system. They play a vital role in defending the body against viral infections, intracell
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23rd Sep 2024
Th17 Cell Differentiation: Insights into Immunological Dynamics
Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of au
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25th May 2024