Blog

Cyclins and CDKs are central to cell cycle control, with specific cyclin-CDK pairs regulating different phases, ensuring orderly progression and genomic integrity in cell division. Key Takeaways: Cyclins and CDKs are vital for cell cycle regulation. Cyclins A, B, D, E each pair with specific CDKs to control cell cycle phases. Cdk1, the prototypical CDK, partners with cyclin B for mitotic entry. Cyclin B upregulation and Cdk1 substrates play key roles in mitosis. Proteomic analysis reveals extensive Cdk1 substrates in mitosis. Positive feedback loops amplify Cdk1/cyclin B activity. Cdk1-Plk1 phosphorylation cascade is crucial for spindle assembly and mitosis. Cyclin degradatio …

What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motility, and morphogenesis. The majority of HGF is produced by the liver, but it is also expressed in other organs, such as the kidney, pancreas, and intestine. HGF binds to its cognate receptor, c-Met, which is present on the surface of many types of cells. However, it has no measurable protease activity. Binding of HGF to c-Met leads to activation of multiple signaling pathways that promote cell proliferation, survival, migration, and differentiation. Key Takeaways Hepatocyte Growth Factor …