Blog
Fluorescence spectroscopy: An early detection tool for cancer.
Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early underst
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11th Mar 2021
A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer
Mechanical forces are common in biological systems and dominate numerous perturbations that are relevant to human physiology and disease. Mechanobiology is a new field that evaluates the eff
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11th Mar 2021
Pancreatic Cancer and its Poor Prognosis
Myrna Hurtado, PhD Student, University of North Texas Health Science Center
Advancements in modern medicine have resulted in significantly prolonging and a
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11th Mar 2021
Polo-like kinase (Plk1) substrates and mitosis
Polo-like kinase (Plk1)
Polo-like kinase (Plk1), is a serine/threonine kinase that is active during mitosis (Hamanaka et al., 1995). Its name is derived from its origi
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10th Mar 2021
Barrett’s Oesophagus to Oesophageal Adenocarcinoma – Review
Oesophageal Adenocarcinoma is on the rise globally affecting more than 450,000 people worldwide (Pennathur, Gibson et al. 2013). Once diagnosed overall 5-year survival ranges from 15 % to 2
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10th Mar 2021
AKT Signalling – Mini Review
Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). AKT
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9th Mar 2021
HMGB1 in inflammation and cancer
HMGB1 Functional Overview
High mobility group box 1 (
HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 an
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9th Mar 2021
Immuno Oncology: If cancer was a pathogen, would a vaccine be able to destroy it?
Thanks to the great intuitions of brilliant scientists like Louis Pasteur, Edward Jenner, Robert Koch, Emil von Behring, Gaston Leon Ramon, Albert Sabin, Jonas Salk in the past century, the
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9th Mar 2021
miRNAs as therapeutics and biomarkers for pancreatic cancer
Pancreatic cancer survival rates
Despite
recent advances in our understanding of this disease, pancreatic cancer is one
of the world’s most lethal malignan
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9th Mar 2021
Estrogen and Breast Cancer: a Nuclear (Receptor) War
By Dr. Lisa Dwane, Postdoctoral Researcher, Royal College of Surgeons in Ireland
The first link between estrogen and breast cancer was made in the l
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9th Mar 2021
Androgenic steroid action in breast cancer
By Rachel Bleach, PhD Student, RCSI
By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reported
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9th Mar 2021
LATS1/2 Kinases Review
LATS kinases belong to a family of proteins that, in mammals, are comprised of two isoforms, LATS1 and LATS2. Originally identified in Drosophila melanogaster as Warts kinase, LATS1 and LATS2 se
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11th Jan 2021
Cancer & Tumour Suppressors – Mini Review
Cancer DevelopmentCancer is a group of diseases that involves abnormal cell growth resulting in malignant tumours/ malignant neoplasms. Cancer is a leading cause of morbidity, with 14 million ne
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18th Dec 2020
Ras signaling pathway
A wide variety of cell surface receptors activate Ras GTPase, including the tyrosine receptor linked to the epidermal growth factor receptor (EGFR) (Wells 1999). Upon receptor stimulation, son o
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18th Dec 2020
Inhibiting cell division
Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surrounding
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18th Dec 2020
Early Diagnosis is key: Pick the weed or allow it destroy the garden?
By CatrÃona Dowling, Post-Doc, RCSI
I want you to come on a journey with me where we are going to the botanic gardens. You will pick a section of the garden that is yours: yours to treasure
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18th Dec 2020
Cancer Research Club March 2020
ELISA Genie is delighted to announce the date of our next Cancer Research Club which will be taking place on the 31st of March at TTMI, Trinity College Dublin. This event will focu
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16th Dec 2020
Hepatocellular Carcinoma - Methyltransferase expression
Hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers and there are 630,000 new cases diagnosed every year worldwide (De Minicis et al. 2013). HCC develops frequently fr
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1st Jan 1970
Colorectal Cancer Review (CRC) - Assay Genie
By Charlotte O’Donnell PhD
Cancer
Carcinogenesis is a multi-step process that develops through epigenetic changes and
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1st Jan 1970
Liposomal nanosilver encapsulation for cytotoxic assays
Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatmen
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1st Jan 1970
Pathological functions of IL-33/ST2 in IBD and Cancer
By Charlotte O'Donnell PhD
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1st Jan 1970
Tumour Inflammation & Signaling | Assay Genie
By Charlotte O’Donnell PhD
Inflammation and Cancer
The link between inflammation and cancer is well established, with infl
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1st Jan 1970