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CB6, also known as Etesevimab, is a monoclonal antibody that targets the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. It neutralizes the virus by preventing it from binding to the angiotensin-converting enzyme 2 (ACE2) receptor on human cells. CB6 has been studied in combination with other antibodies, such as Bamlanivimab, for treating mild to moderate COVID-19 and preventing disease progression. The biosimilar HDBS0011 replicates CB6’s efficacy and safety while providing a cost-effective option for broader global access.This article explores the mechanism of action, clinical applications, and potential benefits of HDBS0011 in addressing the COVID-19 pandemic.1 …

SARS-CoV-2, the causative viral agent of the novel coronavirus disease COVID-19, has sparked a global effort for creating prophylactic and therapeutic interventions. The following five companies have released information on upcoming treatments or preventative measures. 1. Gilead — Remdesivir Remdesivir (GS-5734) is a broad spectrum antiviral nucleotide analogue which has shown promising results as a therapeutic in compassionate-use cases. Currently, it is in Phase 3 clinical trials across Asia and “other countries...with high numbers of diagnosed cases”. Two Phase 3 trials are running concurrently: the firs …

What is COVID-19 COVID-19, the disease caused by the coronavirus named SARS-CoV-2, first identified in Wuhan, China in December 2019 has spread globally, resulting in the ongoing 2019-2020 coronavirus pandemic. This disease is spread by the release of aerosol droplets that can be transmitted via person-to-person if they are within two meters of an infected person for 15 minutes or longer. The most common symptoms of coronavirus are fever, cough, shortness and breath or breathing difficulties. In more severe cases, pneumonia or severe acute respiratory syndrome may occur and these cases require hospitalisation. …

Seroconversion Implications in SARS-CoV-2 Diagnostic Testing Key Points: COVID-19, the pandemic coronavirus disease caused by SARS-CoV-2, has been shown to follow a typical seroconversion and immunoglobulin class (isotype) switching time course, according to preliminary data. A strong positive correlation between clinical severity and antibody titer two weeks after symptom onset was reported. COVID-19 Background: SARS-CoV-2 Structure & Infiltration SARS-CoV-2, the causative viral agent of the disease COVID-19, is a coronavirus …

COVID-19 Antibody Testing Antibody Production in COVID-19 COVID-19, the novel coronavirus disease caused by SARS-CoV-2, can be detected in patients using serological testing. COVID-19 has been shown to follow a standard seroconversion curve. This means that IgM antibodies are produced approximately 12 days after symptom onset by B cell derived plasma cells. These IgM antibodies are later outnumbered by the more robust IgG type antibodies, which mark the generation of a maturing or secondary immune response. The process of switching from primarily IgM to primarily IgG antibodies in the serum …

Workplace Testing for COVID-19 Corporate Testing for COVID-19 The impact of COVID-19 on the economy has been staggering. Current projections imply that the effects of the viral outbreak will be felt for some time. Low cost, high throughput testing has the potential to help institutions and individuals make the best choices for themselves and others.   Simple, point of care assays are the best option for workplace testing. Lateral flow immunoassays are a particularly good choice because they require minimal laboratory equipment and can yield results in as little as 15 minutes. In additi …

Testing for COVID-19 Since the start of the COVID-19 pandemic, the World Health Organisation have emphasised the crucial importance of viral testing. This has therefore led to a huge demand for high-throughput testing of throat and nasopharyngeal samples (Source). The greater number of patients being qualitatively tested for coronavirus, the more treatment can be provided, and the greater the reduction in the rapid spread of this virus. Typically, reverse-transcriptase polymerase chain reaction (RT-PCR) is used for viral diagnostic testing and requires a nasopharyngeal swab for the viral sample. Nasopharyngeal swabs ar …

SARS-CoV-2 검사 키트-코로나 바이러스 검사를위한 원스텝 RT-qPCR 키트 (2019-nCoV 종) 강력하고 재현 가능한 원스텝 코로나 바이러스 검사 (2019-nCoV종) 제품 개요 : 현재 2019-nCoV 또는 COVID-19로 불리는 새로운 코로나 바이러스는 중국 우한에서 진행중인 폐렴 발병 사례의 원인으로 알려졌습니다. Assay Genie Coronavirus COVID-19(2019-nCoV종) 원스텝 RT-qPCR 검사 키트는 실시간 RT qPCR을 사용하여 호흡기 검체에서(가래; 비인두, 구인두, 면봉 및 세척액; 기관 흡인액) 2019-nCoV 또는 COVID-19의 체외 검출을 위해 사용됩니다. Assay Genie Coronavirus COVID-19 (2019-nCoV종) 원스텝 RT-qPCR 감지 키트는 단일 튜브에서 효율적인 cDNA 합성 및 실시간 PCR을 가능하게합니다. 이 키트에는 실시간 PCR을 수행하기 위해 두 배의 농도로 공급되는 qPCR MasterMix 시약이 포함되어 있습니다. qPCR MasterMix (2x) 시약 …

Rapid Antibody & Antigen tests available from Assay Genie SKU Product Name INCP-AC0502 COVID-19 Antigen Rapid Test ICI …

Structure, Function, and Detection Assays for COVID-2019 Background The global spread of the novel coronavirus has sparked international interest in understanding the cellular mechanisms of host infiltration. SARS-Cov-2 (formerly 2019-nCoV) has been identified as the causative viral agent of the disease COVID-19.   Recent efforts to understand SARS-CoV-2 have yielded crucial knowledge in the fight against coronaviruses. Angiotensin-converting enzyme 2 (ACE2) has been implicated as the cellular receptor which facilitates uptake of the virus into the host cell. Thanks to the tireless efforts …

PCR Detection of COVID-19 (SARS-CoV-2) Contents Background Assay Information Sample Types       Upper Respiratory       Lower Respiratory Notes Background COVID-19 (causative agent: SARS-CoV-2), the novel coronavirus which has brought the capital of China’s Hubei province to a standstill, has been deemed a Public Health Emergency of International Concern by the World Health Organisation as of January 2020. (1) Wuhan is the epicentre of the epidemic, but cases have been reported across the world. A large po …

What is the Coronavirus Spike Protein? COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respiratory syndrome coronavirus 2. The most common abbreviation for this virus is SARS-CoV-2.   Coronaviruses are a family of viruses named for their crown-like appearance when imaged (corona being the Latin for crown). The large, type I transmembrane spike glycoprotein accounts for this notable feature. It is a heavily-glycosylated, cell-surface protein which is thought to mediate viral entry into susceptible cells. This spike glycoprotein, called ‘S’, is trimeric in structure. In addi …

Immune Regulation in COVID-19: Immunomodulatory Mechanisms against SARS-CoV-2 Infection What is COVID-19? COVID-19 the disease caused by the coronavirus named SARS-CoV-2 has caused the current COVID-19 global pandemic. This virus is spread via aerosolised droplets that can be produced via coughing or sneezing. In most cases, it causes mild to moderate symptoms including a cough, a fever, shortness of breath or breathing difficulties. However, in more severe cases, it has a greater impact causing pneumonia, acute respiratory distress syndrome and possible multi-organ failure. …

주요 포인트: COVID-19,SARS-COV-2에의한 유행성 코로나 바이러스 질환은 예비 데이터에 따르면, 전형적인 혈청 전환 및 면역 글로불린 클래스 (이소형) 전환 시간 과정을 따르는 것으로 나타났다. 증상 발병 2 주 후 임상 중증도와 항체가의 강한 긍정적 상관 관계가 보고되었습니다. COVID-19 research tools ACE2 Activity Assay Kit Anti-Spike Antibody Recombinant Spike Protein Anti-Nucleocapsid Antibody Recombinant Nucleocapsid Protein SARS-CoV-2 RT qPCR assay SARS-CoV-2 ELISA Kits SARS-CoV-2 Recombinant Proteins Tocilizumab ELISA Kit COVID-19 ELISA Kits, Antibodies & Assays …

Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols What is COVID-19? COVID-19, the disease by the coronavirus, SARS-CoV-2, is currently causing a global pandemic. There is an overwhelming amount of research being done to provide a greater understanding of the disease and the virus that causes it. It is known that the virus is transmitted through person-to-person contact via aerosolised droplets that can be produced through talking, coughing or sneezing. In order for the possibility of infection to occur, a person must be within 15 metres of an infected person for viral particles t …

اختبار COVID-19 POC السريع الوصف إن مجموعة الفحص الجيني تستخدم فقط COVID-19 Rapid POC (Point-of-Care) Kit هو اختبار سريع يكتشف نوعيًا فيروس التاجي 2 لمتلازمة الجهاز التنفسي الحادة الوخيمة (SARS-CoV-2). يوفر استخدام اختبار COVID-19 السريع فرصة لتحديد المزيد من الأشخاص الذين لا يعرفون أنهم مصابون. تفسير النتائج: إيجابية IgG: يظهر خطان ملونان. يجب أن يظهر خط ملون واحد دائمًا في منطقة خط التحكم (C) ويجب أن يكون خط آخر في منطقة خط IgG. إيجابية IgM: يظهر خطان ملونان. يجب أن يظهر خط ملون دائمًا في منطقة خط التحكم (C) ويجب أن يكون خط آخر في منطقة خط IgM. إيجابية I …

COVID-19 15分のRAPID POCテスト 詳細については、hello @ assaygenie.comにお問い合わせください。 概観 Acro Biotech COVID-19 Rapid POC CE-IVDテストは、新規コロナウイルス疾患COVID-19の原因物質であるSARS-CoV-2に対する患者生成IgGおよびIgM抗体の存在を定性的に評価するラテラルフローイムノアッセイです。試験カセットは、全血、血清または血漿検体中のこれらの抗体を検出できます。 パックサイズ テスト 1パック …

RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA helicase which functions as a pattern recognition receptor (PRR) to detect double stranded RNA and other viral PAMPs. RIG-I and RIG-I-like receptors are crucial for viral immunity and can activate a series of pro-inflammatory genes, creating a locally antiviral environment. Contents     Structure     Function         Innate Immune Response         Conferring Viral Immunity   …

Hydroxychloroquine: Potential Treatment for COVID-19 What is Hydroxychloroquine? Hydroxychloroquine (HCQ) belongs a family of medicines called antimalarials, which are also classified as disease-modifying anti-rheumatic agents, or DMARDs. Hydroxychloroquine was previously used to prevent and cure malaria. However, it has also been recognised to treat various other diseases such as rheumatoid arthritis, sarcoidosis (inflammatory disease of the lungs and lymph glands), lupus and Sjogren's syndrome whereby the white blood cells of the body affect the tear and saliva glands, thereby, reducing the amo …

SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potential indicators of disease severity. COVID-19 is the novel coronavirus disease caused by the viral agent SARS-CoV-2. With millions of confirmed cases across the world, the disease represents an unprecedented threat to public health. Additionally, the significant ramifications of an impacted healthcare system further broaden the danger that the virus presents. As the international community rushes to mitigate the economic and social damage the virus continues to cause, researchers seek to elucida …

Tocilizumab (Actemra®) in COVID-19 Treatment What is Tocilizumab? Tocilizumab, also called atlizumab, is an immunosuppressive humanised monoclonal antibody which targets the IL-6 receptor. IL-6 is a cytokine which is involved in many important immune responses—discussed below— but which can also contribute to the pathogenesis of certain diseases, specifically autoimmune diseases and certain types of cancers. Most notably, IL-6 is implicated in cytokine release syndrome and thus targeting it or its receptor is thought to be a promising therapeutic intervention. window. …

SARS-CoV-2 qPCR assay from Assay Genie Assay Genie have just launched a qPCR assay for the detection of SARS-CoV-2. The SARS-CoV-2 One-Step RT-qPCR Kit for Coronavirus Detection (Strain 2019-nCoV) can detect SARS-CoV-2 in a range of sample types including sputum; nasopharyngeal, oropharyngeal aspirates, washes or swabs; tracheal aspirates by qPCR. What is in the kit? The assay genie SARS-CoV-2 qPCR assay kit comes with enough reagents to run 100 reactions. This kit also comes in 5, 10 and 500 pack sizes. Each kit comes with the following reagents for SARS-CoV-2 detection. …

SARS-CoV-2用検出キット-コロナウイルス検出用RT-qPCRワンステップキット（2019-nCoV系統） 堅牢かつ再現性の高いワンステップコロナウイルス検出（2019-nCoV系統）製品の概要： 現在2019-nCoVまたはCOVID-19と呼称されている新コロナウイルスは、中国武漢でアウトブレイクした新型肺炎の原因病原体として発表されました。 Assay Genie コロナウイルスCOVID-19（2019-nCoV系統）ワンステップRT-qPCR検出キットは、リアルタイムRT qPCRを使用して、呼吸器検体中（上咽頭または中咽頭吸引液、気管洗浄液またはぬぐい液）の2019-nCoVまたはCOVID-19の試験管内検出を行います。 Assay Genie コロナウィルス COVID-19（2019-nCoV系統）ワンステップRT-qPCR検出キットは、同一試験管内での効率的なcDNA合成とリアルタイムPCRを行うことができます。 キット内には、リアルタイムPCRのために2倍の濃度のqPCR Master Mixが含まれています。 qPCR Master Mix（2x）には、PCR反応の実行に必要なすべての試薬（PCRプライマー、プローブ、テンプレートを除く）が含まれています。 さらに、RTase（逆転写酵素）とRNase阻害剤とがバランスよく …

COVID-19 Prevention and Treatment What is COVID-19? COVID-19 is an infectious disease caused by the coronavirus, SARS-CoV-2, and infects the airways and lung epithelium. The disease was first identified in Wuhan in China in December 2019, and has since spread globally causing a pandemic. Coronaviruses are a large family of viruses that can cause respiratory or gastrointestinal symptoms. The most common symptoms associated with COVID-19 are fever, cough, shortness of breath and in more severe cases pneumonia and SARS (severe acute respiratory syndrome). It has been established that this virus has …