Blog
Ovarian Cancer: Symptoms, Causes, Diagnosis and Treatment
Ovarian cancer is the fourth most common cancer in women. Ovarian cancer is when the normal cells in the ovary change and grow to form a tumour. Because the ovaries are located deep
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3rd Apr 2022
Chronic myelogenous leukaemia (CML) – Review
Chronic myelogenous leukaemia (CML) is a myeloproliferative haematopoietic malignancy, characterised by a karyotypic abnormality present in more than 95% of cases known as the Philadelph
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1st Apr 2022
Leukemia Inhibitory Factor: An Overview
Leukemia Inhibitory Factor and JAK-STAT Signalling Pathway
Leukemia inhibitory factor (LIF) is a cytokine that belongs to the interleukin-6 (IL-6) family of cytokines. Other members of
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24th Mar 2022
Esophageal Cancer: Causes, Symptoms, Diagnosis, Treatment, and Prevention
Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many di
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21st Mar 2022
Prostate Cancer Markers : What to Look for in Your Test Results
In this blog post, we will review prostate cancer markers and what you should look for in your results. Prostate antigen marker (PSA) and p63 are the most common markers found in pro
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21st Mar 2022
Cancer Research Club - RCSI
Our Cancer Research Club symposium series continued on Wednesday afternoon, at Royal College of Surgeons (RCSI), Dublin, Ireland. The Bouchier-Hayes lecture theatre was at maximum capacity w
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6th Oct 2021
HERV-K group of endogenous retroviruses and cancer
In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germl
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6th Oct 2021
Acute Lymphoblastic Leukaemia Review | Assay Genie
Incidence rate of Acute Lymphoblastic Leukaemia
Acute lymphoblastic leukaemia (ALL) is one of the most common malignant diseases diagnosed in children. It
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20th Aug 2021
The common characteristics of cancer | Assay Genie
By Shane Houston, PhD Candidate Queen’s University Belfast
Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health t
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20th Aug 2021
Cell Signalling – Mini Review
Cell Signalling
Cell signalling pathways have an important role in integrating a plethora of extracellular and intracellular signals to produce a controlled optimal o
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15th Mar 2021
Microcalcifications in breast cancer: Novel insights into the molecular mechanism and functional consequences
Shane O’Grady, PhD student, RCSI
Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades
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15th Mar 2021
How does Acute Myeloid Leukaemia start?
I have been in the situation that I’m sure many of us have. I work on genes, which if you name to any right-minded individual, sound like a random string of nonsensical gibberish. So, maybe
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15th Mar 2021
Platinum based cancer drugs and next generation therapeutics
Platinum based cancer drugs
Despite nearly 50% of all
anti-cancer treatments being platinum-based, there is an urgent need to develop
novel therapeutics
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15th Mar 2021
The double-edged sword in prostate cancer therapy
By Zoe Angel, PhD Student, Ulster University
Prostate cancer is now the commonest cancer in men and it is the fifth leading cause of death (1). Research
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15th Mar 2021
Fluorescence spectroscopy: An early detection tool for cancer.
Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early underst
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11th Mar 2021
A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer
Mechanical forces are common in biological systems and dominate numerous perturbations that are relevant to human physiology and disease. Mechanobiology is a new field that evaluates the eff
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11th Mar 2021
Pancreatic Cancer and its Poor Prognosis
Myrna Hurtado, PhD Student, University of North Texas Health Science Center
Advancements in modern medicine have resulted in significantly prolonging and a
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11th Mar 2021
Polo-like kinase (Plk1) substrates and mitosis
Polo-like kinase (Plk1)
Polo-like kinase (Plk1), is a serine/threonine kinase that is active during mitosis (Hamanaka et al., 1995). Its name is derived from its origi
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10th Mar 2021
Barrett’s Oesophagus to Oesophageal Adenocarcinoma – Review
Oesophageal Adenocarcinoma is on the rise globally affecting more than 450,000 people worldwide (Pennathur, Gibson et al. 2013). Once diagnosed overall 5-year survival ranges from 15 % to 2
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10th Mar 2021
AKT Signalling – Mini Review
Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). AKT
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9th Mar 2021
HMGB1 in inflammation and cancer
HMGB1 Functional Overview
High mobility group box 1 (
HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 an
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9th Mar 2021
Immuno Oncology: If cancer was a pathogen, would a vaccine be able to destroy it?
Thanks to the great intuitions of brilliant scientists like Louis Pasteur, Edward Jenner, Robert Koch, Emil von Behring, Gaston Leon Ramon, Albert Sabin, Jonas Salk in the past century, the
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9th Mar 2021
miRNAs as therapeutics and biomarkers for pancreatic cancer
Pancreatic cancer survival rates
Despite
recent advances in our understanding of this disease, pancreatic cancer is one
of the world’s most lethal malignan
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9th Mar 2021
Estrogen and Breast Cancer: a Nuclear (Receptor) War
By Dr. Lisa Dwane, Postdoctoral Researcher, Royal College of Surgeons in Ireland
The first link between estrogen and breast cancer was made in the l
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9th Mar 2021