Blog
TNFR2: Taming Regulatory T Cells to Enhance Anti-Tumor Immunity
In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly regu
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14th Oct 2024
CD27 Activation: Strengthening the Immune Army Against Cancer
Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activa
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14th Oct 2024
B7-H4: A New Frontier in Immune Checkpoint Inhibition
The recent advances in cancer immunotherapy have brought new opportunities to harness the body’s immune system against tumors. Among these advancements is the targeting of immune checkpoi
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14th Oct 2024
LILT: A Novel Immune Checkpoint for Cancer Therapy
Recent advances in immunotherapy have highlighted the importance of targeting immune checkpoints to enhance the immune system’s ability to combat cancer. A new potential target in this gr
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14th Oct 2024
ICOS: Stimulating the Immune System for Superior Cancer Therapy
Immunotherapy has transformed the landscape of cancer treatment by leveraging the body’s immune system to target and destroy cancer cells. A key player in this process is Inducible T-cell
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14th Oct 2024
PVR: Balancing Immune Activation and Suppression in Cancer
PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a r
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10th Oct 2024
CD28: Amplifying T Cell Responses for Better Tumor Clearance
The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecules
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10th Oct 2024
CD47: Overcoming Tumor Evasion Through Macrophage Activation
One of the greatest challenges in cancer therapy is how tumors evade immune detection. Among the mechanisms cancer cells exploit, the CD47 pathway has emerged as a major player in helping
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8th Oct 2024
4-1BB: Energizing Immune Cells to Overcome Tumor Resistance
Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic res
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8th Oct 2024
OX40 Agonists: Revitalizing the Immune Response in Cancer
Cancer immunotherapy has revolutionized treatment options, offering strategies to harness the immune system to target and destroy tumors. One emerging area of interest is the use of OX40
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8th Oct 2024
Targeting CD200: Unlocking Immune Suppression in Tumors
Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a
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8th Oct 2024
SIRPα Inhibition: Clearing Tumors by Promoting Phagocytosis
Cancer cells are adept at avoiding destruction by the immune system, often exploiting specific pathways to escape detection and elimination. One of these key mechanisms involves the SIRPα
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8th Oct 2024
Harnessing CD40 for Potent Anti-Tumor Immune Responses
CD40, a member of the tumor necrosis factor receptor (TNFR) superfamily, plays a pivotal role in regulating immune responses, particularly in activating antigen-presenting cells (APCs) an
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4th Oct 2024
Targeting VISTA: Unleashing the Power of T Cells in Cancer Therapy
V-domain Ig suppressor of T cell activation (VISTA) is an emerging immune checkpoint receptor that plays a key role in suppressing T cell activity within the tumor microenvironment (TME).
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3rd Oct 2024
B7-H3: A Promising New Target in Tumor Immunotherapy
B7-H3, also known as CD276, is a member of the B7 family of immune checkpoint molecules that has emerged as a compelling target in tumor immunotherapy. Initially recognized for its role i
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3rd Oct 2024
TIM-3: Targeting T Cell Exhaustion for Better Immunotherapy Outcomes
T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to ef
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3rd Oct 2024
GITR: Boosting T Cell Activation for Enhanced Cancer Immunotherapy
Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GITR
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3rd Oct 2024
CD25 and Tregs: Understanding the Role of Regulatory T Cells in Tumor Immunity
Regulatory T cells (Tregs) play a crucial role in maintaining immune balance by suppressing excessive immune responses that could lead to tissue damage. However, in the context of cancer,
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3rd Oct 2024
NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy
Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill cance
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3rd Oct 2024
LAG-3: Revitalizing T Cells in Exhaustion for Combination Therapies
Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target fo
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2nd Oct 2024
TIGIT: A New Frontier in Cancer and Autoimmune Disease Immunotherapy
TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT
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1st Oct 2024
CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells
CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Helpe
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25th Sep 2024
Anti-PD-1: Restoring T Cell Function in Cancer Immunotherapy
Cancer immunotherapy has revolutionized the treatment landscape for various malignancies. One of the most promising therapeutic strategies is the use of immune checkpoint inhibitors, part
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24th Sep 2024
Anti-CTLA-4: Unleashing the Power of T Cells in Combination Immunotherapy
Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to fight malignancies. Among the notable advancements in this field is the development of immune c
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24th Sep 2024