The XRCC6 Polyclonal Antibody (CAB0883) is a vital tool for researchers studying XRCC6, a key protein involved in DNA repair and genomic stability. This antibody, generated in rabbits, is highly specific for XRCC6 in human samples, making it ideal for Western blot analysis. By specifically binding to XRCC6, this antibody enables the visualization and quantification of XRCC6 levels in various cell types, facilitating research in fields such as cancer biology and genomics.XRCC6, also known as Ku70, is a critical component of the non-homologous end joining pathway for DNA double-strand break repair.
Dysregulation of XRCC6 has been linked to genomic instability and increased susceptibility to cancer. By studying XRCC6 expression and function using this antibody, researchers can gain insights into the mechanisms underlying DNA repair and its relevance to disease development.The XRCC6 Polyclonal Antibody (CAB0883) is a valuable tool for advancing our understanding of DNA repair processes and their implications for human health. Its high specificity and reliability make it a trusted choice for researchers seeking to explore the roles of XRCC6 in various biological contexts.
Product Name:
Ku70 Rabbit Polyclonal Antibody
SKU:
CAB0883
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 408-609 of human Ku70 (NP_001460.1).
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Purification Method:
Affinity purification
Gene ID:
2547
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ku70 Rabbit pAb (CAB0883) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
