The XRCC1 Rabbit Monoclonal Antibody (CAB4135) is a powerful tool for researchers studying XRCC1, a key protein involved in DNA repair processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting XRCC1 in human samples, making it an excellent choice for Western blot applications.XRCC1 is essential for repairing single-strand breaks in DNA and plays a crucial role in maintaining genomic stability. Dysregulation of XRCC1 has been linked to an increased risk of cancer and other genetic disorders, making it a significant target for research in the fields of oncology and genomics.
By utilizing the XRCC1 Rabbit Monoclonal Antibody, researchers can accurately detect and analyze XRCC1 protein levels in various cell types, providing valuable insights into DNA repair mechanisms and potential therapeutic targets. This antibody is a valuable tool for studies aimed at understanding the role of XRCC1 in DNA damage response pathways and its impact on human health.
Product Name:
XRCC1 Rabbit Monoclonal Antibody
SKU:
CAB4135
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human XRCC1 (P18887).
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Purification Method:
Affinity purification
Gene ID:
7515
Clone Number:
ARC0915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using XRCC1 Rabbit mAb (CAB4135) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
