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XRCC1 Rabbit Monoclonal Antibody (CAB4135)

SKU:
CAB4135
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:XRCC1 Rabbit Monoclonal Antibody
SKU:CAB4135
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human XRCC1 (P18887).
Sequence:MPEI RLRH VVSC SSQD STHC AENL LKAD TYRK WRAA KAGE KTIS VVLQ LEKE EQIH SVDI GNDG SAFV EVLV GSSA GGAG EQDY EVLL VTSS FMSP SESR
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:RCC; SCAR26; XRCC1
Positive Sample:K-562,Mouse testis,Rat testis
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:69kDa
Observed MW:82kDa

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Purification Method:Affinity purification
Gene ID:7515
Clone Number:ARC0915
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using XRCC1 Rabbit mAb (CAB4135) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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