The VPREB3 Polyclonal Antibody (PAC0424-14) is a valuable tool for researchers studying VPREB3, a gene involved in B-cell development and differentiation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards VPREB3 in human samples, making it an excellent choice for Western blot applications. By binding specifically to the VPREB3 protein, researchers can accurately detect and analyze its expression in various cell types, facilitating studies in immunology and cancer research.
VPREB3, also known as Immunoglobulin lambda-like polypeptide 1, plays a crucial role in B-cell receptor signaling and maturation. Understanding the function of VPREB3 is essential for unraveling the complexities of B-cell development and its dysregulation in diseases such as leukemia and lymphoma. By using the VPREB3 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treating them.
Antibody Name:
VPREB3 Antibody (PACO42414)
Antibody SKU:
PACO42414
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Pre-B lymphocyte protein 3 protein (21-122AA)
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Synonyms:
Pre-B lymphocyte protein 3 (N27C7-2) (Protein VPreB3), VPREB3
UniProt Protein Function:
VPREB3: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. Belongs to the immunoglobulin superfamily.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 22q11.23|22q11Cellular Component: endoplasmic reticulum; extracellular spaceBiological Process: immune response; immunoglobulin production
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
