VAMP1/VAMP2/VAMP3 Antibody (PACO03098)
- SKU:
- PACO03098
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
VAMP1/VAMP2/VAMP3 Antibody (PACO03098)
The VAMP1/VAMP2/VAMP3 Antibody (PACO03098) is a versatile tool for researchers studying vesicle-associated membrane proteins (VAMPs) involved in membrane fusion and exocytosis. This polyclonal antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.VAMPs are essential for the transport of vesicles containing neurotransmitters, hormones, and other molecules to the cell membrane for release. By targeting VAMP1, VAMP2, and VAMP3 proteins, this antibody enables the detection and analysis of these key players in membrane trafficking processes across various cell types.
Research in neuroscience, endocrinology, and cell biology can benefit from the use of this antibody to study the mechanisms underlying vesicle fusion and release. Understanding the functions of VAMPs is crucial for unraveling their roles in synaptic transmission, hormone secretion, and other physiological processes regulated by vesicle exocytosis.
| Antibody Name: | VAMP1/VAMP2/VAMP3 Antibody |
| Antibody SKU: | PACO03098 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human VAMP-1/2/3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | VAMP1; SYB1; Vesicle-associated membrane protein 1; VAMP-1; Synaptobrevin-1; VAMP2; SYB2; Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; VAMP3; SYB3; Vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptob |
| UniProt Protein Function: | VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p Cellular Component: cell junction; cell surface; cytosol; integral to plasma membrane; mitochondrial outer membrane; synaptic vesicle membrane; terminal button Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: vesicle fusion Disease: Spastic Ataxia 1, Autosomal Dominant |
| NCBI Summary: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P23763 |
| NCBI GenInfo Identifier: | 135093 |
| NCBI Gene ID: | 6843 |
| NCBI Accession: | P23763.1 |
| UniProt Secondary Accession: | P23763,O75468, Q15857, Q6FG94, Q8IVC9, A8MVP3, D3DUR3 |
| UniProt Related Accession: | P23763 |
| Molecular Weight: | 12,658 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 1 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 1 |
| NCBI Official Symbol: | VAMP1Â Â |
| NCBI Official Synonym Symbols: | SYB1; SPAX1; VAMP-1Â Â |
| NCBI Protein Information: | vesicle-associated membrane protein 1 |
| UniProt Protein Name: | Vesicle-associated membrane protein 1 |
| UniProt Synonym Protein Names: | Synaptobrevin-1 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP1Â Â |
| UniProt Entry Name: | VAMP1_HUMAN |
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