The USP43 Polyclonal Antibody (PAC022672) is a valuable tool for researchers studying USP43, a protein involved in regulating cellular processes. This antibody was raised in rabbits and is highly specific for detecting USP43 in human samples, making it suitable for Western blot applications. By binding to USP43, this antibody enables precise detection and analysis of USP43 levels in various cell types, making it a versatile tool for studying molecular mechanisms and potential therapeutic targets.USP43, a deubiquitinating enzyme, is known to play a role in regulating protein stability and turnover, making it an important player in various cellular pathways.
Research on USP43 has implicated its involvement in cell cycle progression, DNA repair, and signal transduction, suggesting its potential as a target for drug development in cancer and other diseases. By understanding the functions and regulatory mechanisms of USP43, researchers can uncover new insights into cellular processes and potentially identify novel therapeutic strategies.
Antibody Name:
USP43 Antibody (PACO22672)
Antibody SKU:
PACO22672
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human USP43.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from JK cells, using USP43 antibody.
Background:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.
USP43: May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.19.12; Ubiquitin-specific protease; ProteaseChromosomal Location of Human Ortholog: 17p13.1Cellular Component: nucleoplasmMolecular Function: ISG15-specific protease activityBiological Process: bypass DNA synthesis
