Anti-UGT1A6 Antibody (CAB17165)
- SKU:
- CAB17165
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-UGT1A6 Antibody (CAB17165)
The UGT1A6 Polyclonal Antibody (CAB17165) is a vital tool for researchers studying UGT1A6, an enzyme involved in the metabolism and detoxification of various molecules in the body. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.UGT1A6 is a key player in drug metabolism and the conjugation of substances for elimination from the body. Research on UGT1A6 is crucial for understanding drug interactions, toxicity, and personalized medicine approaches.
The UGT1A6 Polyclonal Antibody enables precise detection and analysis of UGT1A6 protein levels in different cell types, providing valuable insights for pharmacology and toxicology studies.With its ability to target UGT1A6, this antibody is a valuable tool for investigating the role of this enzyme in drug metabolism, xenobiotic detoxification, and diseases related to impaired metabolic processes. Researchers can rely on the UGT1A6 Polyclonal Antibody to support their research in pharmacogenomics, drug development, and precision medicine applications.
| Antibody Name: | Anti-UGT1A6 Antibody |
| Antibody SKU: | CAB17165 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLLK ESKY YTRK IYPV PYDQ EELK NRYQ SFGN NHFA ERSF LTAP QTEY RNNM IVIG LYFI NCQS LLQD RDTL NFFK ESKF DALF TDPA LPCG VILA EYLG LPSV YLFR GFPC SLEH TFSR SPDP VSYI PRCY TKFS DHMT FSQR VANF LVNL LEPY LFYC LFSK YEEL ASAV LKRD VDII TLYQ KVSV WLLR YDFV LEYP RPVM PN |
| Gene ID: | 54578 |
| Uniprot: | P19224 |
| Cellular Location: | |
| Calculated MW: | 29kDa/50kDa/60kDa |
| Observed MW: | Refer to figures |
| Synonyms: | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F, UDPGT1-6 |
| Background: | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. |
| UniProt Protein Function: | Ugt1a6a: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Carbohydrate Metabolism - pentose and glucuronate interconversions; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - ascorbate and aldarate; Mitochondrial; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 2q37 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein homodimerization activity; enzyme binding; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; xenobiotic metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; cellular response to hormone stimulus |
| NCBI Summary: | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19224 |
| NCBI GenInfo Identifier: | 340141 |
| NCBI Gene ID: | 54578 |
| NCBI Accession: | AAC41717.1 |
| UniProt Secondary Accession: | P19224,Q96TE7, A6NKK6, B8K289, |
| UniProt Related Accession: | P19224 |
| Molecular Weight: | 50,528 Da |
| NCBI Full Name: | UDP-glucuronosyltransferase, partial |
| NCBI Synonym Full Names: | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| NCBI Official Symbol: | UGT1A6Â Â |
| NCBI Official Synonym Symbols: | GNT1; UGT1; HLUGP; UDPGT; UGT1F; HLUGP1; UGT1A6S; UDPGT 1-6Â Â |
| NCBI Protein Information: | UDP-glucuronosyltransferase 1-6; UGT-1F; UGT1*6; UGT1-06; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; phenol-metabolizing UDP-glucuronosyltransferase; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s |
| UniProt Protein Name: | UDP-glucuronosyltransferase 1-6 |
| UniProt Synonym Protein Names: | Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6 |
| Protein Family: | UDP-glucuronosyltransferase |
| UniProt Gene Name: | UGT1A6Â Â |
| UniProt Entry Name: | UD16_HUMAN |
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