The UGT1A1 Monoclonal Antibody (CAB22609) is a powerful tool for researchers studying the UGT1A1 enzyme, which plays a vital role in the metabolism of drugs and xenobiotics in the liver. This monoclonal antibody has been specifically designed for use in various research applications, including Western blot and immunohistochemistry.Developed using state-of-the-art technology, this antibody offers high specificity and sensitivity for detecting UGT1A1 protein in human samples. Its ability to bind specifically to UGT1A1 makes it an invaluable asset for researchers studying drug metabolism, pharmacokinetics, and personalized medicine.
The UGT1A1 enzyme is essential for the detoxification and elimination of numerous drugs and toxins from the body, making it a key player in drug metabolism and drug-drug interactions. By using the UGT1A1 Monoclonal Antibody (CAB22609), researchers can gain valuable insights into the regulation and activity of this enzyme, leading to a better understanding of how drugs are processed in the body and potentially improving drug safety and efficacy in clinical settings.
Product Name:
UGT1A1 Monoclonal Antibody
SKU:
CAB22609
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human UGT1A1 (NP_000454.1).
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Purification Method:
Affinity purification
Gene ID:
54658
Clone Number:
ARC57754
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using UGT1A1 antibody (CAB22609) at 1:4000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
