The UBR2 Polyclonal Antibody (PAC013056) is a valuable tool for researchers studying UBR2, a protein involved in the ubiquitination pathway and regulation of protein turnover. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.UBR2 is a key player in the ubiquitin-proteasome system, where it plays a role in targeting specific proteins for degradation. Dysregulation of this pathway has been linked to various diseases, making UBR2 an important target for research in cancer, neurodegenerative disorders, and metabolic diseases.
By using the UBR2 Polyclonal Antibody, researchers can effectively detect and analyze UBR2 protein levels in different cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for studies in cell biology, molecular biology, and biochemistry, helping to advance our understanding of protein turnover and its impact on disease pathology.
ubiquitin protein ligase E3 component n-recognin 2;UBR2;C6orf133;DKFZp686C08114;KIAA0349;MGC71112;RP3-392M17.3;bA49A4.1;dJ242G1.1;dJ392M17.3 ;
UniProt Protein Function:
UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complexMolecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination
UniProt Protein Details:
NCBI Summary:
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
