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TTR Monoclonal Antibody [PAT7B2AT] (CPAB0429)

SKU:
CPAB0429
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT7B2AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

TTR Monoclonal Antibody [PAT7B2AT] (CPAB0429)

The TTR Polyclonal Antibody (CPAB0429) is a versatile tool for researchers studying Transthyretin (TTR), a protein involved in various physiological processes including transporting thyroid hormones and vitamin A. This antibody, produced in rabbits, is highly specific to human TTR and has been validated for use in Western blotting and immunohistochemistry applications.TTR is known for its involvement in amyloidosis, a group of disorders characterized by the abnormal buildup of amyloid proteins in tissues and organs.

Research into TTR aggregation and its implications in neurodegenerative diseases like Alzheimer's and familial amyloid polyneuropathy has gained significant interest. The TTR Polyclonal Antibody allows for the detection and analysis of TTR expression in a variety of samples, making it an essential tool for investigating TTR-related diseases and developing potential therapeutic interventions.

Product Name:TTR Antibody
Product Sku:CPAB0429
Size:5μg
Host Species:Mouse
Immunogen:Anti-human TTR mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TTR amino acids 21-147 purified from Ecoli.
Clone:PAT7B2AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:TTR antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Transthyretin (TTR) is a circulating and abundant tetramer, which functions as a carrier protein of thyroid hormone and retinol binding protein. It is primarily produced in the liver, but also in the brain and eye. Mutations in the TTR gene cause the protein to dissociate into monomers that after misfolding assemble into amyloid fibrils deposits in a variety of organs. TTR is also the only gene known to be associated with familial TTR amyloidosis. The diseases that originate from mutations in the TTR gene include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Synonyms:Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB, HsT2651.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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