TSC1 Rabbit Monoclonal Antibody (CAB5121)
- SKU:
- CAB5121
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TSC1 Rabbit Monoclonal Antibody |
SKU: | CAB5121 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1065-1164 of human Hamartin (Q92574). |
Sequence: | TTMG EASA SIPT TVGS LPSS KSFL GMKA RELF RNKS ESQC DEDG MTSS LSES LKTE LGKD LGVE AKIP LNLD GPHP SPPT PDSV GQLH IMDY NETH HEHS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | LAM; TSC; TSC1 |
Positive Sample: | HT-1080 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein. |
Calculated MW: | 130kDa |
Observed MW: | 150kDa |
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method: | Affinity purification |
Gene ID: | 7248 |
Clone Number: | ARC1236 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |