The TREM2 Polyclonal Antibody (CAB10482) is a vital tool for researchers studying TREM2, a cell surface receptor known for its role in immune response modulation and neurodegenerative diseases. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TREM2 protein, this antibody facilitates the detection and analysis of TREM2 in a variety of cell types, making it an ideal choice for studies in immunology and neurological research.TREM2, also known as Triggering Receptor Expressed on Myeloid cells 2, is a key regulator in the activation of microglia and the clearance of cellular debris in the brain.
Dysregulation of TREM2 has been implicated in various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Understanding the function and expression of TREM2 is essential for developing targeted therapies aimed at treating these debilitating conditions.By using the TREM2 Polyclonal Antibody (CAB10482), researchers can advance their understanding of TREM2 signaling pathways and its impact on neurological health. This valuable tool enables precise detection and analysis of TREM2, ultimately aiding in the development of novel treatments for neurodegenerative diseases.
Product Name:
TREM2 Rabbit Polyclonal Antibody
SKU:
CAB10482
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-161 of human TREM2 (NP_061838.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
25kDa
Observed MW:
55kDa
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
54209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung using TREM2 Rabbit pAb(CAB10482) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:30s.
